What is the most significant work of art of the 20th century?

It is difficult to point out a single work as the most significant of the 20th century, since it was a period of great effervescence and revolution in art, with multiple avant-garde and groundbreaking proposals. However, some works that had a great impact and influence could be:

The Young Ladies of Avignon (1907) by Pablo Picasso:
This Cubist painting by Picasso marked a radical break with Western artistic tradition by deconstructing and geometricizing human figures. He opened the way to abstraction and modern art.

The Fountain (1917) by Marcel Duchamp:
By exposing a simple urinal as "ready-made", Duchamp questioned traditional concepts of art and proposed that everyday objects could be elevated to the category of art by the artist's sole intention. A revolutionary idea.

Guernica (1937) by Pablo Picasso:
This monumental work is a heartbreaking cry against the violence and suffering caused by the Spanish Civil War. Her striking cubist style and powerful political symbolism make her an anti-military icon.

The Persistence of Memory (1931) by Salvador Dalí:
Perhaps the most recognizable surrealist work, with its famous clocks melting over a dreamlike and disturbing landscape. It represented the breakdown of rational logic in art.

The Glitter Boxes (1964) by Andy Warhol:
These sculptures reproducing Campbell's soup boxes exemplify pop art and how mundane objects and themes of mass culture became artistic motifs.

Although it is impossible to achieve a consensus, these works sowed the seeds of important artistic movements, broke conceptual barriers and opened new paths for creative expression in the turbulent 20th century.